Search results for " immunoglobulin"
Article
From Darwin to Recombinant Fc Multimers
CSL was interested to test the approach of topical application of immunoglobulins into the lungs and performed initial feasibility assessment studies of nebulization of IgG. The conclusion was that ne…
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Report from the 12th Plasma Product Biotechnology Forum
It was the consensus that immunoglobulins will remain as the key driver for plasma fractionation market, and even if alternative therapies are getting stronger, they will not totally replace IVIG (int…
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Antibody Production in Microbial Hosts
Since the advent of an era of antibody-based therapeutics, the major focus of the industry has been on the generation of antibodies with glycosylation patterns similar to the naturally occurring immun…
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Antibody Purification Handbook
The use of recombinant technology opens up the potential to create an infinite number of combinations between immunoglobulins, immunoglobulin fragments, tags and selected proteins, further manipulatin…
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Advances in Engineering of Protein-Based APIs
Bi/multispecific proteins
Bispecific antibodies are an important emerging area in advancing protein engineering for pharmaceutical products, and several bispecifics based on immunoglobulin scaffol…
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Fusion Proteins Pose Manufacturability Challenges
This TNFα blocker consists of a tumor necrosis factor receptor (TNFR) and an immunoglobulin (Ig) G1 Fc segment. The TNFR provides specificity and the Fc segment increases the stability.
In fact, t…
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Witnessing Major Growth in Next-Generation Antibodies
Because they involve a simple single heavy-chain immunoglobulin (Ig) domain, there are no heavy/light chain pairing issues seen with other mAb-based bi-specific platforms. It is possible to geneticall…
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Affinity Chromatography Handbook: Vol. 1 Antibodies
The use of recombinant technology opens up the potential to create an infinite number of combinations between immunoglobulins, immunoglobulin fragments, tags and selected proteins, further manipulatin…
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Single-Domain Antibodies for Brain Targeting
Crystal and solution structures of several sdAbs adopt a β-sheet structure similar to a VH or VL immunoglobulin fold in a conventional antibody. sdAbs have similar affinity to antigens as whole antibo…
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HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
Of the classes of immunoglobulins, IgG1 is the most commonly used for pharmaceutical and biomedical purposes.2
In recent years, increased understanding of disease and advances in drug discover…